The Endocrinology Laboratory is considered one of the most important departments of our laboratory. Its high quality has been confirmed by the multiple distinctions (1st & 2nd place) received in the Murex International and BIORAD Laboratory Quality Control Programs, with a participation of 300 European Laboratories, out of which just 12 are Greek ones.
These honorary distinctions are the result of implementation of Internal Quality Control Programs since 1981, as well of the hard and persistent efforts of our scientific staff, complemented by the use of new techniques and automatic immunological analyzers.
The laboratory is equipped with unique in Greece, fully automatic, Roche Diagnostics and Siemens systems. There are two Roche Diagnostics pre-analytical systems; one is connected to a quadruple Modular Ε 170 immunologic analyzer with a capacity of over 680 samples per hour, whereas the other is connected to a triple Modular Ε 170 immunologic analyzers with a capacity of 510 samples per hour. Also, a Siemens Labcell automated analyzer is connected with four Advia Centaur and two Immulite 2000 analyzers, performing thus1000 sample analyses per hour.
The laboratory is also equipped with 16 automatic immunological analyzers (1 Axsym, 1 Abbott IMX, 3 Abbott Architect, 1 Roche Elecsys 2010), with 1 TECAN automatic fluid dispenser and 1 gamma-radiation tester.
In the context of the full computerization of the laboratory, this equipment allows for the daily execution of all common hormone analyses, whereas even the rarest of hormone analyses are executed on a regular basis.
The catecholamine and dopamine quantitative tests and their fractional separation are carried out with the HPLC method, while the quantitative tests of steroid hormones in newborns and infants is carried out by using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/ mass spectrometry (LC-MS/MS) systems.
The 6-steroid-hormone profile test (17-OH-progesterone, DHEA, D4-Androstenedione, Testosterone, Pregnenolone and Cortisol) is well-established in the diagnosis of both congenital hyperplasia of the suprarenal glands in infants and the same syndrome in adults. Furthermore,the 5-steroid hormone profile test (6 above hormones minus Pregnenolone) is used in the diagnosis of the polycystic ovaries syndrome and its differentiation from the congenital hyperplasia of the suprarenal glands.
The GC/MS method is also the choice method for testing for hypoandrogeny or hyperandrogenemia in women, as well as for monitoring androgen reduction therapy cases, i.e. women's hyperandrogenemia or men's prostate cancer.
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